Atlanta (March 14, 2006) — Researchers at the Georgia Institute of Technology and the University of California, San Francisco, have found an even more effective and safer way to detect and kill cancer cells. By changing the shapes of gold nanospheres into cylindrical gold nanorods, they can detect malignant tumors hidden deeper under the skin, like breast cancer, and selectively destroy them with lasers only half as powerful as before – without harming the healthy cells. The method, which allows for a safer, deeper penetrating noninvasive cancer treatment, has just appeared in the Journal of the American Chemical Society, volume 128.

Many cancer cells have a protein, known as Epidermal Growth Factor Receptor (EFGR), all over their surface, while healthy cells typically do not express the protein as strongly. By conjugating, or binding, the gold nanorods to an antibody for EFGR, suitably named anti-EFGR, researchers were able to get the nanoparticles to attach themselves to the cancer cells.

In this latest study, researchers incubated two malignant oral epithelial cell lines and one benign epithelial cell lines with nanorods conjugated to anti-EFGR. Not only were the malignant lines clearly identifiable as such under a simple optical microscope, but after being exposed to a continuous sapphire laser in the near infrared spectrum, the malignant lines only required half the laser energy to kill them as the healthy cells.

"This makes it more practical than the sphere in terms of treating cancer,” said Mostafa El-Sayed. “For laser phototherapy treatment of skin cancer or, for diagnostic biopsies, the spheres are fine, but for phototherapy of cancer deep under the skin, like breast cancer, then one really needs to use the nanorods treatment.”

Related Links

Mostafa El-Sayed
http://www.chemistry.gatech.edu/faculty/El-Sayed/

Ivan El-Sayed
http://cc.ucsf.edu/people/el-sayed_ivan.html

The Georgia Institute of Technology is one of the nation's premiere research universities. Ranked ninth among U.S. News & World Report 's top public universities, Georgia Tech educates more than 17,000 students every year through its Colleges of Architecture, Computing, Engineering, Liberal Arts, Management and Sciences. Tech maintains a diverse campus and is among the nation's top producers of women and African-American engineers. The Institute offers research opportunities to both undergraduate and graduate students and is home to more than 100 interdisciplinary units plus the Georgia Tech Research Institute. During the 2004-2005 academic year, Georgia Tech reached $357 million in new research award funding. The Institute also maintains an international presence with campuses in France and Singapore and partnerships throughout the world.