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Biophan Details Latest Patent Rights;
Depiction of Technology Available Online

ROCHESTER, N.Y.--(BUSINESS WIRE)--Aug. 10, 2004--Biophan Technologies, Inc. (OTC BB: BIPH), a leading developer of next-generation biomedical technology, provided additional detail today on its broad U.S. Patent issued to Nanoset, LLC, its technology partner, with Biophan holding the worldwide, exclusive rights for all medical applications. The patent rights relate to a nanomagnetic particle coating technology which can provide illumination for devices that are currently difficult to see, either because they are invisible to MRI or because the devices occlude the MRI image. As noted in the earlier release, the patented technology is expected to help pave the way to allowing MRI-guided surgical procedures when combined with Biophan's safety solutions, including minimally invasive procedures, such as those used for placing stents, performing RF ablation, angiograms, biopsy probes, and many other procedures.

Mr. Weiner noted, "In the interest of providing additional detail regarding the patent, it should be noted that the variations in the coating, as taught in the patent and covered in the patent claims, can allow us to coat the tip with a very bright coating that can help guide the catheter placement through vessels or tissue; and make the rest of the catheter visible but less prominent, so its position can be seen. Many MRI machines already in the field have software built in that can track a catheter that emits the proper signal, so it can be viewed in the operating theater during a procedure. Until now, the combination of device heating and image artifacts has prevented the emergence of MRI as a tool for guided procedures. Our technology suite can now allow the transition to MRI guided surgery to move forward."

U.S. Patent No. 6,765,144 was issued to Nanoset, LLC, with Biophan holding the worldwide exclusive rights to all medical applications. Biophan and Nanoset worked jointly on the innovation, based on earlier nanotechnology patents developed by Nanoset. A copy of the patent can be viewed on the Company's website at http://www.biophan.com/intellectual.php.

In the actual MRI image, which can be viewed on the Company's website at http://www.biophan.com/visiblecoating.php, an aluminum rod is on the third position from the left, and is almost invisible. The same type of rod is shown in the middle position and on the left-hand position, with the Nanoset/Biophan thin-film coating, and the rod is now very visible in the same MRI image. Biophan is utilizing its thin-film coating technology to introduce a controllable, "magnetic" signal capable of creating an image of the coated device. The visibility, or equivalent of "brightness," can be controlled.

About Nanoset, LLC
Nanoset, LLC, based in East Rochester, NY, develops nanomagnetic particle coatings. Nanoset's research and development has been conducted with Alfred University, a world leader in ceramics and thin-film coatings. Nanoset and Biophan are jointly developing technologies for the medical device industry.

About Biophan Technologies
Biophan Technologies develops and markets cutting-edge technologies designed to make biomedical devices safe and compatible with magnetic resonance imaging (MRI) equipment. The Company develops enabling technologies for implanted medical systems such as pacemakers, and interventional surgical devices such as catheters and guidewires, as well as stents and other implants that can be safely and effectively imaged under MRI. The technology is also being used to create enhanced MRI contrast agents. Committed to growth through innovation and developmental leadership, Biophan and its licensors have 16 issued U.S. patents and 60 patents pending, in areas including nanotechnology (nanomagnetic particle coatings), radio frequency filters, polymer composites, biothermal batteries, and photonics. Biophan's technology will help realize its goal of one day making all biomedical devices capable of safely and successfully working with MRI. For more information, please visit www.biophan.com.

 

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